Abstract Search

10.1. Transition to adult diabetes care in Germany - high risk for acute complications and declining metabolic control during the transition phase

TM Kapellen , S Muther , A Schwandt , J Grulich-Henn , B Schenk , KO Schwab , W Marg , RW Holl

Pediatr Diabetes. 2018 Apr 25. doi: 10.1111/pedi.12687. [Epub ahead of print]Transition of patients with chronic diseases from pediatric to adult care has become recognized as an important part of health care provision and its multifaceted challenges are increasingly being studied. This transition period is associated with deterioration of metabolic control and general health in young adults wi...

0 shares

ey0018.7-3 | Clinical Guidance | ESPEYB18

7.3. Phase 3 trial of a small-volume subcutaneous 6-month duration leuprolide acetate treatment for central precocious puberty

KO Klein , A Freire , MG Gryngarten , GB Kletter , M Benson , BS Miller , TS Dajani , EA Eugster , N Mauras

J Clin Endocrinol Metab. 2020 Oct 1;105(10):e366071. 10.1210/clinem/dgaa479. https://academic.oup.com/jcem/article/105/10/e3660/5879679In brief: This phase 3 multi-centre, open-label, single-arm study explores the efficacy, pharmacokinetics and safety of 6-monthly 45-mg subcutaneous leuprolide acetate in 59 pati...

0 shares

ey0015.14-9 | The ancient wisdom of refraining from consanguinity | ESPEYB15

14.9 Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers

M Sikora , A Seguin-Orlando , VC Sousa , A Albrechtsen , T Korneliussen , A Ko , S Rasmussen , I Dupanloup , PR Nigst , MD Bosch

To read the full abstract: Science 2017:eaao1807Consanguinity is common in some modern cultures. This study examined the question whether ancient humans, who often had limited choices of mates, bred among close relatives. Here, Sikora et al. report genome sequences from 4 early humans buried close together in western Russia about 34,000 years ago. The individuals ...

0 shares

ey0020.2-8 | Long-Acting Growth Hormone (LAGH) | ESPEYB20

2.8. Efficacy and safety of weekly somatrogon vs daily somatropin in children with growth hormone deficiency: A phase 3 study

CL Deal , J Steelman , E Vlachopapadopoulou , R Stawerska , LA Silverman , M Phillip , HS Kim , C Ko , O Malievskiy , JF Cara , CL Roland , CT Taylor , SR Valluri , MP Wajnrajch , A Pastrak , BS Miller

Brief summary: This 12-months randomized, controlled, phase 3 study compared the efficacy and safety of once-weekly Somatrogon 0.66 mg/kg/week with once-daily somatropin in prepubertal children with GHD. The efficacy of once-weekly Somatrogon was noninferior to once-daily somatropin, with similar safety and tolerability profiles.Somatrogon (MOD-4023) is a long-acting rhGH recently approved by the European Medicines Agency for the treatment of children wi...

1 shares

ESPE Yearbook of Paediatric Endocrinology

10.1. Transition to adult diabetes care in Germany - high risk for acute complications and declining metabolic control during the transition phase

7.3. Phase 3 trial of a small-volume subcutaneous 6-month duration leuprolide acetate treatment for central precocious puberty

14.9 Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers

2.8. Efficacy and safety of weekly somatrogon vs daily somatropin in children with growth hormone deficiency: A phase 3 study

BiosciAbstracts